diff --git a/include/sys/spa_impl.h b/include/sys/spa_impl.h
index 44afa7632..588c72f6e 100644
--- a/include/sys/spa_impl.h
+++ b/include/sys/spa_impl.h
@@ -250,6 +250,7 @@ struct spa {
 	uint64_t	spa_min_ashift;		/* of vdevs in normal class */
 	uint64_t	spa_max_ashift;		/* of vdevs in normal class */
 	uint64_t	spa_min_alloc;		/* of vdevs in normal class */
+	uint64_t	spa_gcd_alloc;		/* of vdevs in normal class */
 	uint64_t	spa_config_guid;	/* config pool guid */
 	uint64_t	spa_load_guid;		/* spa_load initialized guid */
 	uint64_t	spa_last_synced_guid;	/* last synced guid */
diff --git a/module/zfs/spa_misc.c b/module/zfs/spa_misc.c
index 06f640769..3b355e0de 100644
--- a/module/zfs/spa_misc.c
+++ b/module/zfs/spa_misc.c
@@ -772,6 +772,7 @@ spa_add(const char *name, nvlist_t *config, const char *altroot)
 	spa->spa_min_ashift = INT_MAX;
 	spa->spa_max_ashift = 0;
 	spa->spa_min_alloc = INT_MAX;
+	spa->spa_gcd_alloc = INT_MAX;
 
 	/* Reset cached value */
 	spa->spa_dedup_dspace = ~0ULL;
diff --git a/module/zfs/vdev.c b/module/zfs/vdev.c
index b6f8c0ab3..f3812b843 100644
--- a/module/zfs/vdev.c
+++ b/module/zfs/vdev.c
@@ -1399,6 +1399,36 @@ vdev_remove_parent(vdev_t *cvd)
 	vdev_free(mvd);
 }
 
+/*
+ * Choose GCD for spa_gcd_alloc.
+ */
+static uint64_t
+vdev_gcd(uint64_t a, uint64_t b)
+{
+	while (b != 0) {
+		uint64_t t = b;
+		b = a % b;
+		a = t;
+	}
+	return (a);
+}
+
+/*
+ * Set spa_min_alloc and spa_gcd_alloc.
+ */
+static void
+vdev_spa_set_alloc(spa_t *spa, uint64_t min_alloc)
+{
+	if (min_alloc < spa->spa_min_alloc)
+		spa->spa_min_alloc = min_alloc;
+	if (spa->spa_gcd_alloc == INT_MAX) {
+		spa->spa_gcd_alloc = min_alloc;
+	} else {
+		spa->spa_gcd_alloc = vdev_gcd(min_alloc,
+		    spa->spa_gcd_alloc);
+	}
+}
+
 void
 vdev_metaslab_group_create(vdev_t *vd)
 {
@@ -1451,8 +1481,7 @@ vdev_metaslab_group_create(vdev_t *vd)
 				spa->spa_min_ashift = vd->vdev_ashift;
 
 			uint64_t min_alloc = vdev_get_min_alloc(vd);
-			if (min_alloc < spa->spa_min_alloc)
-				spa->spa_min_alloc = min_alloc;
+			vdev_spa_set_alloc(spa, min_alloc);
 		}
 	}
 }
@@ -2213,8 +2242,7 @@ vdev_open(vdev_t *vd)
 	if (vd->vdev_top == vd && vd->vdev_ashift != 0 &&
 	    vd->vdev_islog == 0 && vd->vdev_aux == NULL) {
 		uint64_t min_alloc = vdev_get_min_alloc(vd);
-		if (min_alloc < spa->spa_min_alloc)
-			spa->spa_min_alloc = min_alloc;
+		vdev_spa_set_alloc(spa, min_alloc);
 	}
 
 	/*
diff --git a/module/zfs/zio.c b/module/zfs/zio.c
index 10279fde8..3f5e6a08d 100644
--- a/module/zfs/zio.c
+++ b/module/zfs/zio.c
@@ -1596,6 +1596,19 @@ zio_shrink(zio_t *zio, uint64_t size)
 	}
 }
 
+/*
+ * Round provided allocation size up to a value that can be allocated
+ * by at least some vdev(s) in the pool with minimum or no additional
+ * padding and without extra space usage on others
+ */
+static uint64_t
+zio_roundup_alloc_size(spa_t *spa, uint64_t size)
+{
+	if (size > spa->spa_min_alloc)
+		return (roundup(size, spa->spa_gcd_alloc));
+	return (spa->spa_min_alloc);
+}
+
 /*
  * ==========================================================================
  * Prepare to read and write logical blocks
@@ -1802,9 +1815,8 @@ zio_write_compress(zio_t *zio)
 			 * in that we charge for the padding used to fill out
 			 * the last sector.
 			 */
-			ASSERT3U(spa->spa_min_alloc, >=, SPA_MINBLOCKSHIFT);
-			size_t rounded = (size_t)roundup(psize,
-			    spa->spa_min_alloc);
+			size_t rounded = (size_t)zio_roundup_alloc_size(spa,
+			    psize);
 			if (rounded >= lsize) {
 				compress = ZIO_COMPRESS_OFF;
 				zio_buf_free(cbuf, lsize);
@@ -1847,8 +1859,8 @@ zio_write_compress(zio_t *zio)
 		 * take this codepath because it will change the on-disk block
 		 * and decryption will fail.
 		 */
-		size_t rounded = MIN((size_t)roundup(psize,
-		    spa->spa_min_alloc), lsize);
+		size_t rounded = MIN((size_t)zio_roundup_alloc_size(spa, psize),
+		    lsize);
 
 		if (rounded != psize) {
 			abd_t *cdata = abd_alloc_linear(rounded, B_TRUE);